Naloxone hydrochloride

Application

Naloxone hydrochloride dihydrate has been used in:isotonic saline and injected subcutaneously into experimental rats to study its involvement with withdrawal syndrome in morphine-dependent ratsas opioid receptor antagonist to examine the role of the endogenous opioid system in infantile amnesia for contextual fearas a reference neutral antagonist to define the maximum effect (Emax) of the system

Biochem/physiol Actions

Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites. Naloxone′s antagonistic effect last for about 45 min and thus, requires repeated dosage. It results in critical side effects such as pulmonary edema.

Caution

Light sensitive.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

1, 5 g in poly bottle

250 mg in poly bottle